D-Mannose Natural Defense +


Provides natural support against UTIs*
Supports healthy bladder function*
Supports healthy liver function*

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Health benefits

Natural support or UTIs and healthy bladder and liver function

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Specifically designed for Women

D-Mannose Natural Defense + ingredients maximize the bioavailability in women

100% Drug-free

Made with pure and natural ingredients inside an FDA registered facility that adheres to GMP guidelines

Natures first defense against UTI’s

D-Mannose Natural Defense + is a natural formula that has been specifically designed by health professionals to provide natural support for UTIs, and support healthy bladder and liver function.

D-Mannose (1000mg)

D-mannose is a type of sugar that is closely and often related to glucose. These sugars are both simple sugar consisting of just one molecule of sugar. Both occur naturally in your body and are also found in several fruits and vegetables such as cranberries, apples, peaches, broccoli, and green beans.

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Cranberries (150mg)

Cranberries have been used as a natural treatment for preventing bladder infections for generations. According to a 2012 review, cranberry juice and cranberry tablets show some promise as a remedy for women who frequently get bladder infections.

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Hibiscus (100mg)

Research of Hibiscus shows that it may have several benefits in regard to the urinary tract. The research showed that Hibiscus significantly reduced renal inflammation by virtue of reducing LPS-induced inflammatory factors in patients. This helped urinary clearance and reduced infections.

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Dandelion (100mg)

Chemicals in dandelions may decrease inflammation and swelling and increase the production of urine. Research of dandelion root and its benefits show that it also helps to support the liver’s ability to remove toxins and clear metabolic waste from the body.

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What are the benefits you ask?

D-mannose is a type of sugar, closely related to the better-known glucose, that is found in cranberries and has been shown to be effective in treating UTIs and preventing recurrence. When examining the causes of UTIs it’s important to note that E. coli bacteria are responsible for 90% of cases. Once these bacteria enter the urinary tract, they latch on to cells, grow, and cause infection. Research suggests that D-mannose may help to provide support for and helping to prevent UTIs by stopping these bacteria from latching on.

Provides natural support against UTIs*

Early research shows that taking d-mannose for 13 days might reduce symptoms of UTIs, such as burning and increased urination. Studies also show that D-mannose might work to prevent E. coli bacteria (which is the cause of 90 percents on UTIs) from attaching to your cells and causing the infection. A 2016 report displayed that the majority of the 43 women with an active UTI showed signs of improvement when using D-mannose.

Supports healthy bladder function*

It’s a completely natural approach to optimum bladder health. Rather than destroying the E. coli strain of bacteria causing the infection, D-Mannose will eliminate them from your system. It can be used as both a preventative and to treat a current infection. Be aware that D-Mannose is thought to only work with E. coli, which is responsible for around 90% of Urinary Tract Infections.

Supports healthy liver function*

Studies show that taking d-mannose may decrease the speed of a protein loss and increase liver function. Research also mentions D-mannose may lower blood sugar and reduce blood clotting disorders. This is especially true in people with a rare inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b.

Nuzena Quality Certification

As part of Nuzena’s commitment to formula quality and transparency, we have now developed our own quality certification tracker so you can now see the ingredient quality testing results of each batch of our products in real-time.

All Nuzena formulas are tested for quality, safety, and efficacy using a trusted 3rd party laboratory. You may download the most recent results of our ingredient testing at any time using the link below.

Joel L. Nelson – Laboratory Manager

Summit Test Laboratories

The D-Mannose Natural Defence + formula has been 3rd party tested using the BioLumix microbiology system to detect traces of various contaminating ingredients to ensure the highest possible quality in our ingredients.

E.coli – Passed

Salmonella – Passed

Staphylococcus aureus – Passed

Yeasts & Molds – Passed

The D-Mannose Natural Defence + formula has been 3rd party tested in accordance with USP (United States Pharmacopeia) standard <2232> ‘Elemental Contaminants In Dietary Supplements’ toxicology reporting.

Arsenic – Passed

Cadmium – Passed

Lead – Passed

Mercury – Passed

D-Mannose Natural Defense + has been tested for traces of allergens and is compliant to quality protocols and commitments. All verifications are completed inside an FDA registered facility that also adheres to GMP guidelines.

Gluten Free – Passed

Vegan Friendly – Passed

Non-GMO – Passed

Backed by scientific research

The ingredients used in our formulas are all backed up by scientific research by health professionals and institutions. Take a look at what some of the worlds most reputable sources have to say.


“Cranberries may help prevent bacteria from attaching to cells in the wall of the urinary tract and causing infection. If you get recurrent UTIs, talk to your doctor or nurse about taking cranberry products to prevent UTIs.”

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“The results of this study suggest that D-mannose can be an effective aid in acute cystitis management and also a successful prophylactic agent in a selected population; however, more studies will certainly be needed to confirm the results of our pilot study.”

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“Treatment recommendations for both treatment and prevention of recurrent UTIs include Botanicals such as Oregon grape root (Berberis aquifolium), uva ursi (Arctostaphylos), cranberry (Vaccinium macrocarpon), pipsissewa (Chimaphila umbellata)and D-mannose.”

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Why Nuzena?

A few reasons why our customers love us.

Clinically Proven Ingredients
Free Personal Health Specialist Included
Free-Shipping Over $50
Simple & Easy Returns
Made With Natural Ingredients
Non-GMO Formulas
Gluten-Free Formulas
Pure & Efficient Extracts
Sustainably Sourced
Made In An FDA Registered Facility

Product reviews

See what our customers have to say.

  1. Tiffany Morgan

    My doctor recommended I try D-mannose and I am so happy I did, girls wonders.

  2. Elisabeth Figueroa

    I try to be as natural as possible and I try to avoid antibiotics when I can, I get bad UTIs and had to take antibiotics, I’ve been taking natural D mannose for 2 bottles now and so far so good, not antibiotics yet!

  3. Marina York

    My friend swears by Nuzenas’ D-mannose, just ordered 3 months to give it a good try.

1 2 3 4

Paige Hatheway

“I’ve been a fan and user of Nuzena’s products since I first discovered them in 2019. I use multiple products in their line every month, but I honestly don’t know where I’d be without D-Mannose. Seriously I havnt had one UTI since I began taking it regularly. This is a 10/10 must have for me.”


Do I need a prescription to buy D-Mannose Natural Defense +?

No, you do not need a prescription to purchase D-Mannose Natural Defense +. D-Mannose Natural Defense + is 100% drug-free and is made with natural ingredients

Are there any harmful side effects?

No, there are no harmful side effects of using D-Mannose Natural Defense + as directed. Before taking any supplement, however, it is always best to speak to your doctor to see if the formula is right for you.

How many capsules are in a bottle?

There are 60 capsules inside every bottle of D-Mannose Natural Defense +. This is equivalent to a 1-months supply.

Will this help with preventing or treating UTIs?

While the ingredients inside the D-Mannose Natural Defense + formula are backed by scientific research relating to their benefits for providing natural support for UTIs, supporting healthy bladder function, and support for healthy liver function, this formula is not intended to cure, treat or prevent any diagnosed medical condition.

How do I use D-Mannose Natural Defense +?

You should take 2 capsules of D-Mannose Natural Defense + daily. For the best results take two capsules with a meal or as directed by your healthcare professional.

When can I expect to see the results?

While everyone’s biochemistry is different and individual results will vary, some users may notice the benefits almost immediately. For the best results, we encourage continued use of D-Mannose Natural Defense + for at least 90 days.

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Still looking for more help?

Speak with one of our health specialists today.

The information and content on this website is provided only for informational purposes. It is not meant in any way as a substitute for the professional advice provided by your physician or any other healthcare professional. The statements on this site have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure or prevent any disease.

Additional information

Weight 1.5 kg
Dimensions 90 × 60 × 90 cm
Directions Of Use

As a dietary supplement take two (2) capsules once a day. For best results take 20-30 min before a meal or as directed by your healthcare professional.

Safety Warning

Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. KEEP OUT OF REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.